Introducing Docent Šárka Lehtonen

Introducing Docent Šárka Lehtonen

Docent  Šárka Lehtonen works as a Sigrid Jusélius Senior Research Fellow. The research done by her group Human Brain Disease Modelling focuses on developing novel human-based models to study the mechanisms of neurological diseases. The group works at the A.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland. 

“We focus mainly on understanding the cellular and molecular mechanisms of Parkinson`s disease and the prediction of drug transport into the brain”, describes Šárka. Her lab uses patient-derived brain cells in 2D and 3D culture systems to accurately mimic the pathological conditions in the diseased brain more accurately.

The key projects focus on studying  

Midbrain organoids as Parkinson’s disease models
LRRK2-mutation and glial cells in Parkinson’s disease
Blood-brain barrier on a chip for disease modelling and drug testing
Generation of Lewy bodies in dopaminergic neurons
Microglia in α-synucleinopathies 

Human Brain Disease Modelling research group (Lehtonen Lab):  

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